The Hidden Dangers of PFAS: How “Forever Chemicals” Penetrate the Skin
Recent research has revealed a significant health concern: 15 different perfluoroalkyl substances (PFAS), often called “forever chemicals,” can infiltrate the skin barrier and reach the bloodstream. Published in Environment International, this study sheds light on a previously underestimated exposure route for these toxic substances. Our dermatologists in Jupiter are here bringing you the latest news to protect your skin best!
In-Depth Analysis of PFAS Skin Absorption
The study investigated 17 different PFAS compounds, focusing on those regulated under the EU’s Drinking Water Directive due to their widespread use and well-documented toxic effects. Remarkably, 15 tested substances exhibited notable dermal absorption, with at least 5% of the exposure dose permeating the skin.
Perfluorooctanoic acid (PFOA), one of the most regulated PFAS, showed a 13.5% absorption rate into the bloodstream. Moreover, 38% of the applied dose of PFOA remained within the skin, indicating potential for longer-term circulation uptake.
Study Methodology and Key Findings
Using 3D human skin equivalent models, researchers conducted dermal absorption studies. While PFAS have been known to enter the body through inhalation and ingestion via food and water, this study is the first comprehensive assessment confirming significant skin absorption.
Dr. Oddný Ragnarsdóttir, the lead author, conducted this research during her PhD at the University of Birmingham. She explained, “Previously, the ability of these chemicals to be absorbed through the skin was dismissed because the molecules are ionized. Their electrical charge, which repels water and stains, was thought to prevent them from crossing the skin membrane. Our research shows this isn’t always true, and skin absorption could be a major exposure route for these harmful chemicals.”
Carbon Chain Length and Absorption Levels
The study discovered a link between the length of the carbon chain in PFAS molecules and their absorption levels. Compounds with longer carbon chains had lower absorption rates, while shorter-chain PFAS, which replaced longer-chain variants like PFOA, were more easily absorbed through the skin.
Public Health Implications
These findings emphasize revising safety protocols and regulations regarding PFAS exposure. With skin absorption emerging as a significant exposure route, further research and public awareness are vital to mitigate health risks.
For more information on PFAS and their impact on dermatology, listen to the Dermalorian Podcast episode “Some Things Last Forever: PFAS and Dermatology” with Dr. Michelle Hure.
The discovery that PFAS can be absorbed through the skin highlights an overlooked aspect of chemical exposure. This study calls for action from regulatory bodies and the public to address and reduce the risks associated with these persistent chemicals.
